Heart Valve Replacements with Regenerative Capacity
نویسندگان
چکیده
منابع مشابه
Heart Valve Replacements with Regenerative Capacity.
The incidence of severe valvular dysfunctions (e.g., stenosis and insufficiency) is increasing, leading to over 300,000 valves implanted worldwide yearly. Clinically used heart valve replacements lack the capacity to grow, inherently requiring repetitive and high-risk surgical interventions during childhood. The aim of this review is to present how different tissue engineering strategies can ov...
متن کاملRegenerative medicine approach to heart valve replacement.
Approximately 275 000 patients receive a heart valve replacement annually. Their choices and the choices of their surgeons are limited to either a metal valve replacement or a preserved (typically allogeneic or xenogeneic) tissue valve replacement. These patients are then subject to the morbidity associated with anticoagulation when mechanical valves are used or the limited durability of a biol...
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King in 1940, in this journal, described appearances that he believed to be those of myocardial regeneration in a case where death had occurred four days after a stab wound of the chest. A review of the literature, however, shows the opinion most generally held is that hyperplasia of cardiac muscle does not occur. Another consideration prompted the present study: Le Gros Clark (1946) showed tha...
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A histological and radioautographic examination of 11 autologous fascia lata heart valves used in man is described. There was a significant decrease, exponential with time, in the number of fibroblasts per unit volume (P<0 001). The collagen bundles were grossly disorganized and separated, suggesting a breakdown of the cross-linkage in the tissue. Redundant connective tissue on the surface of t...
متن کاملProsthetic valve leakage following cardiac valve replacements.
Thirty cases were evaluated in order to study the etiology of prosthetic valvular dehiscence in view of its continued occurrence in a small percentage of cases. The clinical course, management, initial valvular pathology, as well as findings at reoperation and necropsy were the main basis of this study. Factors in the genesis of prosthetic valvular dehiscence in the early and late groups seemed...
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ژورنال
عنوان ژورنال: Transfusion Medicine and Hemotherapy
سال: 2016
ISSN: 1660-3796,1660-3818
DOI: 10.1159/000448181